FTO gene on human chromosome 16. The literature has pointed out that specific alleles of the FTO gene are associated with obesity, and genetic variation can affect appetite regulation. Those with genetic variation are prone to hunger, resulting in weight imbalance.
 
Leptin (LEP) is a hormone that involves body weight regulation. Leptin receptor protein is found on the surface of cells in many body organs and tissues, including a part of the brain, called the hypothalamus. The hypothalamus controls hunger and thirst and other functions such as sleep, moods, and body temperature. In the hypothalamus, signaling affects appetite after leptin binds to its receptor. It regulates energy balance by suppressing appetite and reducing fat storage in adipocytes. Studies have shown that this protein is related to various endocrine functions. Those with genetic mutations are prone to weight imbalance and obesity.